盐酸曲美他嗪对老年心衰患者血浆脑钠肽及6

本实验观察曲美他嗪对慢性充血性心力衰竭（CHF）患者心功能的影响。

Toobserveinfluenceoftrimetazidineoncardiacfunctioninpatientswithchronicheartfailure（CHF）.

70例符合入选标准的CHF患者按数字表法被随机均分为曲美他嗪组和常规治疗组，各35例。常规治疗组根据病情给予洋地黄、利尿剂、血管紧张素转化酶抑制剂等治疗,曲美他嗪组在常规治疗组基础上加用曲美他嗪，疗程4周，分别于治疗前后检测患者血浆脑钠肽（BNP）水平，并对患者进行6min步行试验（6MWT）。

Accordingtonumbertablemethod,atotalof70CHFpatientsaccordedwithinclusionstandardswererandomlyandequallydividedintotrimetazidinegroupandroutinetreatmentgroup.Accordingtopatient′scondition,routinetreatmentgroupreceiveddigitalis,diuretics,angiotensinconvertingenzymeinhibitorsetcCHFroutinefreatment.Trimetazidinegroupadditionallyreceivedtrimetazidinebasedonroutinetreatment.Thetreatmentperiodwasfourweeks.Plasmabrainnatriureticpeptide（BNP）levelwasmeasuredandpatientsreceived6minwalkingtest（6MWT）beforeandaftertreatment.

两组患者治疗后血浆BNP水平均较治疗前明显降低（P0.01）,且曲美他嗪组降低幅度较常规治疗组降低更显著［（.60±.22）pg/ml比（.89±.61）pg/ml,P0.05］;两组患者治疗后6min步行距离均较治疗前显著增加（P0.01）,且曲美他嗪组增加幅度较常规治疗组更显著［（.06±65.18）m比（.46±51.16）m,P0.01］。

Comparedwithbeforetreatment,therewassignificantdecreaseinplasmaBNPlevelintwogroupsaftertreatment（P0.01）,







































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